Built with Biology: Spaces

Neubase Therapeutics

Mon, 11 Oct 2021 17:18:26 +0000

Almost every human disease is driven by genetics. So what if we could cure every genetic disease, from Alzheimer's to cancer?

These may sound like lofty aspirations. But the team at Neubase Therapeutics has developed a method for temporarily modifying disease-causing genes without permanently altering the genome. The backbone of Neubase's technology is also highly adaptable. If successful, the company could only need to make small tweaks to develop a brand new therapy, avoiding years of difficult and expensive clinical trials.

Tune in to hear more about Neubase's cutting-edge approach and much more!

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Fiona Mischel (Host)

Neubase Therapeutics:

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 9/22/21

Leaps by Bayer & Ada Health

Wed, 22 Sep 2021 08:41:32 +0000

Leveraging patient data looks to play a very significant role in improving disease prevention and treatment, giving medical professionals more time for their patients, and spotting health trends in populations before they reach epidemic levels.

But fulling realizing the potential of patient data is not without challenges. Naveen Krishnan of Leaps by Bayer and Daniel Nathrath of Ada Health discuss integration challenges, patient privacy, the promise of better drug trials, and much, much more!

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Fiona Mischel (Host)

Leaps by Bayer:

Ada Health

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 9/15/21

Wild Earth: Ryan Bethencourt

Thu, 16 Sep 2021 15:42:51 +0000

Going plant-based is one of the best things we can do for the health of our planet. But what about our pets? In the United States, pet food is responsible for 25-30% of the meat industry's environmental footprint. How can we reduce this negative impact while giving our beloved pets the best nutrition?

Meet Wild Earth, a company feeding pets sustainably with fermented koji, veterinary insight, cell culture, and most importantly, a love of animals! Did you know dogs are omnivores? Did you know you could soon have cell culture chicken for your cats? Tune in to get all your sustainable pet questions answered and more!

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Fiona Mischel (Host)

Wild Earth:

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 9/8/21

Cemvita Factory: Tara Karimi and Moji Karimi

Fri, 10 Sep 2021 14:02:16 +0000

Today, CO2 emissions from heavy industries are poisoning our atmosphere and causing climate change. But what if we could capture those CO2 emissions and transform them into valuable products using microbes?

That's exactly what the team at Cemvita Factory is doing! Based in Houston, the company has engineering microbes to turn carbon into useful products like bioethylene, just like how plants turn CO2 into oxygen through photosynthesis.

Tune in to hear from Cemvita's founders about how we can use CO2 as a feedstock in our energy transition to Net Zero.

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Fiona Mischel (Host)

Cemvita Factory:

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 9/1/21

Catalog: Tracy Kambara

Wed, 01 Sep 2021 07:53:54 +0000

Humans have been storing information since the Stone Age. And surprisingly, forms of data storage like painting or rock carving have lasted for millennia. The same cannot be said for more modern methods like cassettes and CDs. How can we store our data for the next millennia if our storage systems have shrinking functional lifespans?

Meet CATALOG, a company working to archive human data in DNA. DNA is one of the most stable molecules we know of and it has a language we can program. Hear how data is stored in DNA, what it takes to fit all of Wikipedia into a test tube, and how we could soon be computing with DNA.

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Fiona Mischel (Host)

CATALOG:

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 8/25/21

Phytolon: Halim Jubran and Tal Zeltzer

Mon, 30 Aug 2021 12:21:52 +0000

Candies, cakes, salad dressing, plant-based meats, butter; all these foods and so many more contain food coloring. Food coloring traditionally came from plants but today it comes from petrochemicals.

But now, the bioengineering company Phytolon has found a new way to make food colorings sustainably--and affordably!--using microbes!

Hear from Phytolon's founders about the science behind their breakthrough, how fabrics could be dyed with the same method, and how starting a company in Israel as Jewish and Arab co-founders is bringing communities and families together.

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Fiona Mischel (Host)

Phytolon:

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 8/18/21

Solugen: Gaurab Chakrabarti and Sean Hunt

Tue, 17 Aug 2021 10:00:06 +0000

Chemicals are fundamental in modern society, from the stability of our infrastructures and the safety of our water. But most of these critical materials typically come from petrochemical sources. Now Solugen, a biochemicals company using cell-free enzyme manufacturing, has made the world's first carbon-negative chemical plant for key water treatment ingredients.

Hear how the company has taken over an old petrochemical manufacturing plant in Texas, literally transforming the unsustainable methods of the past into the sustainable--and more cost-effective--methods of the future.

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Fiona Mischel (Host)

Solugen:

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Learn more about Race Against the Clock here!

Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 8/4/21

Indie Bio: Aja Labs & MicroTERRA

Fri, 13 Aug 2021 17:05:31 +0000

Building cool technology is all well and good but it's no good if it doesn't actually help our communities. Meet three powerful entrepreneurs who are solving problems with biology that so many others have overlooked or ignored.

Hear how Marissa Cuevas at MicroTerra is solving challenges for farmers with plant-based ingredients and how Osahon Ojeaga and Mary Ellen Moore at Aja Labs are creating plant-based hair extensions that help our planet and human rights. These IndieBio startups are blazing new trails with new leadership and new vision.

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Fiona Mischel (Host)

Marissa Cuevas

Aja Labs

IndieBio

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 7/28/21

Culture Biosciences: Masaki Yamada and Kris Tyner

Wed, 28 Jul 2021 12:32:01 +0000

Do you have an idea of how to change the world with biology? Great! How are you going to know out if it works at scale in an affordable way? This is one of the big challenges Culture Biosciences is trying to solve with coffee-cup size bioreactors, cloud-based data, and remote lab capabilities.

Hear from Masaki Yamada and Kris Tyner, Product Manager and Senior Bioprocessessing Engineer discuss the challenges of scaling biomanufacturing, the impacts of COVID-19, their favorite applications of Culture's bioreactors, and much more!

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Fiona Mischel (Host)

Culture Biosciences:

@culturebiosci
https://www.culturebiosciences.com/

Subscribe to the Built with Biology Digest for Spaces shows, news across the bioengineering world, upcoming events, and more!

Learn more about Race Against the Clock here!

Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 7/21/21

Jellatech: Stephanie Michelsen

Fri, 16 Jul 2021 16:00:13 +0000

Do you love gummy bears? Or jello? Or your vitamin capsules? Ok, maybe not the last two but you probably also like wine. But what do these have in common? Gelatin and collagen.

These ingredients, which come from the leftovers of pig and cow slaughter for meat, are extremely useful but are currently not sustainable and are often unsafe for workers processing them.

Enter Jellatech, the first company in the world making these incredible ingredients using cellular agriculture. Hear Jellatech co-founder and CEO Stephanie Michelsen explore the science, opportunities, and teeny tiny cell-based gummy bears in this week's Spaces show!

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Fiona Mischel (Host)

Stephanie Michelsen

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Learn more about Race Against the Clock here!

Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 7/14/21

Mammoth Biosciences: Janice Chen

Thu, 15 Jul 2021 11:00:30 +0000

What is CRISPR? How does it work? Is it safe? How could this technology - one of the most powerful scientific tools of the 21st century - reshape our future, from the medicines we take to the foods we eat? Janice Chen, Chief Technology Officer of Mammoth Biosciences, explores the technology and envisions a future powered by CRISPR.

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Fiona Mischel (Host)

Janice Chen

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 6/30/21

Nautilus: Parag Mallick

Fri, 18 Jun 2021 22:31:28 +0000

We spend a lot of time about DNA and the genome, all the genetic material in a living organism. But what about all the proteins? More unique and complex than DNA, proteins control much of how our bodies function and act as targets for therapeutics. Until recently, studying the proteome (all the proteins in an organism) was extremely difficult. Hear Parag Mallick from Nautilus tell the story of why everything may be about to change.

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Fiona Mischel (Host)

Parag Mallick

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 6/16/21

Herophilus : Saul Kato and Sharath Hegde

Wed, 16 Jun 2021 16:08:50 +0000

Why haven't therapeutics for brain diseases improved in decades? Could new approaches using brian organoids (aka mini-brains on a chip!) advance the field and bring potential cures to millions in need? Listen to Saul Kato and Sharath Hegde of Herophilus explain why inspirations of the past may point the way forward to a huge leap in treatments for brain disease.

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Fiona Mischel (Host)

Herophilus:

Saul Kato:

@neurotheory

Sharath Hegde:

@sheg46

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 6/9/21

DNA Script: Sylvain Gariel

Wed, 16 Jun 2021 16:08:43 +0000

What if you could make DNA in a box, put it on the back of a truck, take it to a hot zone, and start making vaccines directly at the epicenter of an emerging pandemic? That's exactly the kind of tech that Sylvain Gariel and the team at DNA Script are working on. Listen to how DNA can be made in a box using enzymes, where the DNA industry is headed, and much more

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Fiona Mischel (Host)

Sylvain Gariel

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Want to learn more about DNA and how it's made? Check out our article on where the DNA industry is going: The DNA Industry is Going Cell-Free

Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 6/4/21

GenScript: Kay Chuang

Wed, 16 Jun 2021 16:05:54 +0000

How are the ingredients for CRISPR gene-editing technology like guide RNAs actually made? And what happened to the grad students trying to ship DNA to their house in the middle of a pandemic? Kay Chuang from GenScript shares great insights, surprising stories, and much more

Want to ask your question live in one of our shows? Be sure to follow @SynBioBeta! #builtwithbiospaces

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Fiona Mischel (Host)

Kay Chuang:

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 6/2/21

Nuclera, Motif Foodworks, & Artificial

Wed, 16 Jun 2021 15:58:12 +0000

Welcome to the first episode of Built with Biology Spaces! Have you ever thought about how biology could change the world? Did you even know that it could? This week's guests are turning science fiction into reality!

Hear how biology is changing the world from artificial intelligence to digital microfluidics, to stretchy, melty plant-based cheese. Listen to guests Michael Chen from Nuclera, Dilek Uzunalioglu from Motif Foodworks , & Nikhita Singh from Artificial, share their stories, insights, and expertise!

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Fiona Mischel (Host)

Michael Chen:

Dilek Uzunalioglu:

Nikhita Singh:

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Episode credits: Hosted by Fiona Mischel, produced by Nikita Michelsen, and recorded, edited, and engineered by Bryce Joseph-Nelson

Recorded: 5/19/21 on Clubhouse